Suppression of TGFβand Angiogenesis by Type VII Collagen in Cutaneous SCC
نویسندگان
چکیده
منابع مشابه
Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC.
BACKGROUND Individuals with severe generalized recessive dystrophic epidermolysis bullosa (RDEB), an inherited blistering disorder caused by mutations in the COL7A1 gene, develop unexplained aggressive squamous cell carcinomas (SCC). Here we report that loss of type VII collagen (Col7) in SCC results in increased TGFβ signaling and angiogenesis in vitro and in vivo. METHODS Stable knockdown (...
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15 صفحه اولIncreased invasive behaviour in cutaneous squamous cell carcinoma with loss of basement-membrane type VII collagen.
Type VII collagen (ColVII) is the main component of anchoring fibrils, attachment structures within the lamina densa of the basement membrane that are responsible for attachment of the epidermis to the dermis in skin. Mutations in the human ColVII gene, COL7A1, cause the severe inherited blistering disorder recessive dystrophic epidermolysis bullosa (RDEB) affecting skin and mucosae, associated...
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Collagen VII, the major component of cutaneous anchoring fibrils is expressed at a low level by normal human keratinocytes and fibroblasts in vitro. In cocultures of these two cell types, signals from fibroblasts enhance expression of collagen VII by keratinocytes and vice versa. In this study, the effects of a possible mediator of such a stimulation, transforming growth factor-beta (TGF-beta),...
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ژورنال
عنوان ژورنال: Journal of the National Cancer Institute
سال: 2015
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/djv293